Sensing the environment

Research in the lab aims to understand how cells sense and interact with their surroundings and how membrane proteins and lipids contribute to signaling, mucosal immunity and cellular metabolism. 

Projects in the lab use a variety of approaches and span several aspects of physiology and disease, including both basic science and translational research.  Our lab uses high resolution quantitative imaging, electrophysiology, organoids, and mouse genetic models to investigate the cellular environment. An important aspect of our research also involves the development of novel optical methods and other tools for studying tissue and cell biology. 
Lab News
September 2023: The Gut-Age Team gathers for an in-person meeting in Boston - great to meet everyone in person and think about science collectively! 

September 2023: Congratulations to Lianna for her CZI Next-Gen Award and AGA Fellow to Faculty Award!!

August 2023: Our paper studying enteroids from patients with Microvillus Inclusion Disease is published in JCI and makes the front cover!   

June 2023: Congratulations to Casey on his Pediatric Scientist Development Program Award!

November 2022: Stephen and David's big review of congenital diarrheas and enteropathies is published in Human Genetics.  

October 2022: Our collaboration with Isaac Chiu's lab on nociceptor control of mucus secretion in the gut is published in Cell

July 2022: Our COACH high school students present their work at lab meeting. 

May 2022: Congratulations to Katlynn on her F32 and her review on lipids and polarity! Check it out here.

October 2021: The lab receives funding from the CZI as art of their Pediatric Networks initiative to coordinate the creation of a single cell map of the early childhood gut across ancestry, geography and environment (GUT-AGE)! See here or on our projects page for more details.

August 2021: The lab receives R35 funding from the NIGMS to study redox signaling and regulation!

July 2021: Our collaboration with Charlie Evavold (from Jon Kagan's lab) and his paper on Gasdermin oligomerization and mTORC regulation via ROS was just published in Cell! Check it out here.  

April 2021: Lab Hike in the Blue Hills! Good to be together outside of the lab at last. Pics here.

Older news here.